Section: Application Domains

Surface Enhanced Raman Spectroscopy

(joint project with HEGP, AP-HP, and Lip(Sys)2, Université Paris-Saclay)

The objective of this work is to evaluate the feasibility of an evolving technique, surface enhanced Raman spectroscopy (SERS) for the analysis of cytotoxic drug concentration. This technique using silver nanoparticles was applied for quantitative analysis of 5-fluorouracil, one of the most widely used molecules in oncology [8].

In view of the high spectral variability observed between the various repetitions of the experiment, and the observed nonlinear interaction between signal concentration and intensity, nonlinear regression methods that take these variabilities into account have been developed.